Carbamazepine (All indications)

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9653
R34362		 Bànhidy (Carbamazepine), 2011 Poly/syndactyly throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.30 [0.01;8.33] C 0/10   2/12 2 10
ref
Total 1 studies 0.30 [0.01;8.33] 2 10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Carbamazepine), 2011Bànhidy, 2011 1 0.30[0.01; 8.33]2100%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.30[0.01; 8.33]210 -NABànhidy (Carbamazepine), 2011 1 Type of controls unexposed, sickunexposed, sick 0.30[0.01; 8.33]210 -NABànhidy (Carbamazepine), 2011 1 Tags Adjustment   - No  - No 0.30[0.01; 8.33]210 -NABànhidy (Carbamazepine), 2011 1 MatchedMatched 0.30[0.01; 8.33]210 -NABànhidy (Carbamazepine), 2011 1 All studiesAll studies 0.30[0.01; 8.33]210 -NABànhidy (Carbamazepine), 2011 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 9.42[0.13; 693.03]3,0901,51482%NAKällén (Carbamazepine) (Controls unexposed, NOS) (Indications NOS), 2013 D'Souza (Carbamazepine) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 1.95[0.23; 16.74]48517%NABànhidy (Carbamazepine), 2011 Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 D'Souza (Carbamazepine) (Controls unexposed, sick), 1991 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.63[0.44; 5.94]103,4680%NATomson (Carbamazepine), 2018 Källén (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2013 20.510.01.0