Carbamazepine (All indications)

Diaphragmatic hernia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9664
R34410		 Jentink (Carbamazepine), 2010 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 0.90 [0.10;6.60] 1/-   -/- - -
ref
Total 1 studies 0.90 [0.11;7.31] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jentink (Carbamazepine), 2010Jentink, 2010 1 0.90[0.10; 6.60]--0%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.90[0.11; 7.31]-- -NAJentink (Carbamazepine), 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.11; 7.31]-- -NAJentink (Carbamazepine), 2010 1 Tags Adjustment   - Yes  - Yes 0.90[0.11; 7.31]-- -NAJentink (Carbamazepine), 2010 1 All studiesAll studies 0.90[0.11; 7.31]-- -NAJentink (Carbamazepine), 2010 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.66[0.31; 8.82]3785120%NABlotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 Jentink (Carbamazepine), 2010 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.95[0.08; 47.99]1512 -NABlotière (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 10.510.01.0