Methotrexate (Pre-conception only)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10346
R37888		 Dawson, 2014 Major birth defects preconceptional for kinetic reason case control unexposed (general population or NOS) Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Any or not specified MTX less than 3 months before pregnancy 0.92 [0.18;4.72] C 5/7   27,618/37,729 27,623 7
ref
Total 1 studies 0.92 [0.18;4.72] 27,623 7
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dawson, 2014Dawson, 2014 0.92[0.18; 4.72]27,62370%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.92[0.18; 4.72]27,6237 -NADawson, 2014 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.92[0.18; 4.72]27,6237 -NADawson, 2014 1 Tags Adjustment   - No  - No 0.92[0.18; 4.72]27,6237 -NADawson, 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 0.92[0.18; 4.72]27,6237 -NADawson, 2014 1 Indications   - Any or not specified  - Any or not specified 0.92[0.18; 4.72]27,6237 -NADawson, 2014 1 MTX less than 3 months before pregnancyMTX less than 3 months before pregnancy 0.92[0.18; 4.72]27,6237 -NADawson, 2014 1 All studiesAll studies 0.92[0.18; 4.72]27,6237 -NADawson, 2014 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.25[0.42; 3.71]27,6561210%NADawson, 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 2 unexposed, sick controlsunexposed, sick controls 1.19[0.07; 19.35]289 -NASvirsky, 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.10[0.29; 4.12]18114 -NAWeber-Schoendorfer (Controls exposed to other treatment, sick), 2014 10.510.01.0