Thiouracil, propylthiouracil, benzylthiouracil

Carbimazole embryopathy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3380
R8737		 Clementi, 2010 Choanal atresia or omphalocele (as a part of Carbimazole embryopathy) 1st trimester case control unexposed (general population or NOS) Adjustment: No 0.90 [0.06;14.53] C 0/94   212/36,168 212 94
ref
Total 1 studies 0.90 [0.06;14.53] 212 94
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clementi, 2010Clementi, 2010 0.90[0.06; 14.53]212940%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.90[0.06; 14.53]21294 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.06; 14.53]21294 -NAClementi, 2010 1 Tags Adjustment   - No  - No 0.90[0.06; 14.53]21294 -NAClementi, 2010 1 All studiesAll studies 0.90[0.06; 14.53]21294 -NAClementi, 2010 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.92; 2.82]2,24310,0240%NASeo (control unexposed, NOS), 2018 Clementi, 2010 2 unexposed, sick controlsunexposed, sick controls 1.36[0.03; 68.71]-1,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.12[0.03; 0.45]3411,32923%NASeo (control exposed to MMI), 2018 Yoshihara (control exposed to MMI), 2012 20.510.01.0