TNF-alpha inhibitors

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3103
R4822		 Vinet, 2013 Induced abortions during pregnancy (anytime or not specified) case control unexposed, sick Adjustment: Yes 2.07 [0.81;5.27] 7/186   105/5,781 112 186
ref
Total 1 studies 2.07 [0.81;5.28] 112 186
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vinet, 2013Vinet, 2013 2.07[0.81; 5.27]1121860%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.07[0.81; 5.28]112186 -NAVinet, 2013 1 Type of controls unexposed, sickunexposed, sick 2.07[0.81; 5.28]112186 -NAVinet, 2013 1 Tags Adjustment   - Yes  - Yes 2.07[0.81; 5.28]112186 -NAVinet, 2013 1 All studiesAll studies 2.07[0.81; 5.28]112186 -NAVinet, 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.72[0.79; 3.76]28691577%NACarman - Etanercept (Controls unexposed, disease free), 2017 Weber-Schoendorfer, 2015 Diav-Citrin (Controls unexposed, disease free), 2014 3 unexposed, sick controlsunexposed, sick controls 1.18[0.83; 1.67]4105940%NADrechsel, 2020 Carman - Etanercept (Controls unexposed, sick), 2017 Vinet, 2013 Verstappen, 2011 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.77[0.41; 7.67]883 -NADiav-Citrin (Controls exposed to other treatments), 2014 10.510.01.0