Ondansetron

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3980		 Parker, BDS study, 2018 Limb deficiency 1st trimester case control unexposed, sick Adjustment: Yes 0.70 [0.30;1.60] 7/382   122/5,620 129 382
ref
S2756
R3697		 Parker, NBDPS study, 2018 Limb deficiency 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.50;1.30] 16/269   585/7,083 601 269
ref
Total 2 studies 0.77 [0.51;1.17] 730 651
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 0.70[0.30; 1.60]12938225%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.80[0.50; 1.30]60126975%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.77[0.51; 1.17]7306510.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed, sickunexposed, sick 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - Yes  - Yes 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.94; 1.13]7,69589,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 unexposed, sick controlsunexposed, sick controls 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0