Ondansetron

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3956		 Zambelli-Weiner (Unexposed control, NOS), 2019 Renal collecting system anomalies 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.24 [0.98;1.58] 69/947   7,803/120,909 7,872 947
ref
S2853
R3968		 Parker, BDS study, 2018 Renal collecting system defects 1st trimester case control unexposed, sick Adjustment: Yes 1.20 [0.90;1.60] 74/449   743/6,241 817 449
ref
Total 2 studies 1.22 [1.02;1.47] 8,689 1,396
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 1.24[0.98; 1.58]7,87294759%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, BDS study, 2018Parker, BDS study, 2018 1.20[0.90; 1.60]81744941%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.22[1.02; 1.47]8,6891,3960.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.22[1.02; 1.47]8,6891,3960%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.24[0.98; 1.57]7,872947 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 unexposed, sickunexposed, sick 1.20[0.90; 1.60]817449 -NAParker, BDS study, 2018 1 Tags Adjustment   - Yes  - Yes 1.22[1.02; 1.47]8,6891,3960%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 2 All studiesAll studies 1.22[1.02; 1.47]8,6891,3960%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, BDS study, 2018 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.24[1.00; 1.54]8,04890,6260%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sick controlsunexposed, sick controls 1.20[0.90; 1.60]817449 -NAParker, BDS study, 2018 10.510.01.0