Ondansetron

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3713		 Zambelli-Weiner (Unexposed control, NOS), 2019 Cardiac Defects 1st trimester nested case control unexposed (general population or NOS) excluded Adjustment: Yes 1.43 [1.28;1.61]
excluded (control group) 		303/1,181   29,001/142,107 29,304 1,181
ref
S3041
R4609		 Zambelli-Weiner (Unexposed control, sick), 2019 Cardiac defects 1st trimester nested case control unexposed, sick Adjustment: Yes 1.48 [1.14;1.92] 303/294   29,001/29,001 29,304 294
ref
Total 1 studies 1.48 [1.14;1.92] 29,304 294
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, sick), 2019Zambelli-Weiner, 2019 1 1.48[1.14; 1.92]29,3042940%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.48[1.14; 1.92]29,304294 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 Type of controls unexposed, sickunexposed, sick 1.48[1.14; 1.92]29,304294 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 Tags Adjustment   - Yes  - Yes 1.48[1.14; 1.92]29,304294 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 All studiesAll studies 1.48[1.14; 1.92]29,304294 -NAZambelli-Weiner (Unexposed control, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2757

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.17[0.95; 1.45]59,616117,04286%NAHuybrechts, 2019 Zambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Fejzo (Unexposed control, disease free), 2016 Danielsson, 2014 Andersen, 2013 6 unexposed, sick controlsunexposed, sick controls 1.48[1.14; 1.92]29,304294 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.16[0.48; 2.83]2,15156,53117%NAHuybrechts (Control exposed to other treatment), 2018 Fejzo (Mainly exposed to other treatements, sick), 2016 20.510.01.0