Ondansetron

Pulmonary valve stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2853
R3990		 Parker, BDS study, 2018 Pulmonary valve stenosis 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.40;1.30] 15/390   212/5,712 227 390
ref
S2756
R3707		 Parker, NBDPS study, 2018 Pulmonary valve stenosis 1st trimester case control unexposed, sick Adjustment: Yes 1.20 [0.80;1.70] 37/290   758/7,256 795 290
ref
Total 2 studies 1.05 [0.72;1.52] 1,022 680
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, BDS study, 2018Parker, BDS study, 2018 0.80[0.40; 1.30]22739034%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.20[0.80; 1.70]79529066%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 23% 1.05[0.72; 1.52]1,0226800.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.05[0.72; 1.52]1,02268023%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed, sickunexposed, sick 1.05[0.72; 1.52]1,02268023%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - Yes  - Yes 1.05[0.72; 1.52]1,02268023%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 All studiesAll studies 1.05[0.72; 1.52]1,02268023%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.00[0.18; 22.08]31,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 1.05[0.72; 1.52]1,02268023%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0