Ondansetron

Total anomalous pulm venous return

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2756
R3710		 Parker, NBDPS study, 2018 Total anomalous pulmonary venous return 1st trimester case control unexposed, sick Adjustment: Yes 1.00 [0.40;2.40] 6/259   154/6,652 160 259
ref
Total 1 studies 1.00 [0.41;2.45] 160 259
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parker, NBDPS study, 2018Parker, NBDPS study, 2018 1.00[0.40; 2.40]1602590%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.00[0.41; 2.45]160259 -NAParker, NBDPS study, 2018 1 Type of controls unexposed, sickunexposed, sick 1.00[0.41; 2.45]160259 -NAParker, NBDPS study, 2018 1 Tags Adjustment   - Yes  - Yes 1.00[0.41; 2.45]160259 -NAParker, NBDPS study, 2018 1 All studiesAll studies 1.00[0.41; 2.45]160259 -NAParker, NBDPS study, 2018 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.49; 1.32]34288,446 -NAHuybrechts (Unexposed control), 2018 1 unexposed, sick controlsunexposed, sick controls 1.00[0.41; 2.45]160259 -NAParker, NBDPS study, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.59[0.26; 1.32]2755,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0