Ondansetron

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3943		 Zambelli-Weiner (Unexposed control, NOS), 2019 Septal defects 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.44 [1.28;1.62] 301/1,179   28,666/141,772 28,967 1,179
ref
Total 1 studies 1.44 [1.28;1.62] 28,967 1,179
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 1.44[1.28; 1.62]28,9671,1790%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.44[1.28; 1.62]28,9671,179 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.44[1.28; 1.62]28,9671,179 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 Tags Adjustment   - Yes  - Yes 1.44[1.28; 1.62]28,9671,179 -NAZambelli-Weiner (Unexposed control, NOS), 2019 1 All studiesAll studies 1.44[1.28; 1.62]28,9671,179 -NAZambelli-Weiner (Unexposed control, NOS), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.57[1.17; 2.12]39,4752,52843%NAZambelli-Weiner (Unexposed control, NOS), 2019 Danielsson, 2014 20.510.01.0