Methotrexate (Post-conception)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6761
R19214		 Dawson, 2014 Major birth defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Any or not specified 1.83 [0.40;8.36] C 10/12   27,613/37,724 27,623 12
ref
Total 1 studies 1.83 [0.40;8.36] 27,623 12
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dawson, 2014Dawson, 2014 1.83[0.40; 8.36]27,623120%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.83[0.40; 8.36]27,62312 -NADawson, 2014 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.83[0.40; 8.36]27,62312 -NADawson, 2014 1 Tags Adjustment   - No  - No 1.83[0.40; 8.36]27,62312 -NADawson, 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 1.83[0.40; 8.36]27,62312 -NADawson, 2014 1 Indications   - Any or not specified  - Any or not specified 1.83[0.40; 8.36]27,62312 -NADawson, 2014 1 All studiesAll studies 1.83[0.40; 8.36]27,62312 -NADawson, 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.85[1.20; 6.75]32,6591200%NADawson, 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Viktil (Controls unexposed NOS), 2012 3 unexposed, sick controlsunexposed, sick controls 1.96[0.23; 16.85]523 -NACooper (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.52[0.57; 4.08]411290%NACooper (Controls exposed to other treatment, sick), 2014 Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014 20.510.01.0