id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S3852 R8208 |
Huybrechts, 2019 | Oral clefts | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Intravenous | 0.95 [0.63;1.43] | -/23,866 -/1,762,018 | - | 23,866 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2852 R3861 |
Huybrechts (Control exposed to other treatment), 2018 | Oral clefts | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
1.32 [1.03;1.70] excluded (control group) |
84/55,579 219/185,699 | 303 | 55,579 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2844 R3815 |
Huybrechts (Unexposed control), 2018 | Oral clefts | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.24 [1.03;1.48] | 124/88,446 1,920/1,727,546 | 2,044 | 88,446 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2746 R3894 |
Pasternak, 2013 | Orofacial clefts | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: No | 0.92 [0.26;3.24] C | 3/1,233 13/4,932 | 16 | 1,233 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 1.18 [1.00;1.39] | 2,060 | 113,545 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Unexposed control;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 2852