Ondansetron

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2746
R3938		 Pasternak, 2013 Congenital absence, atresia and stenosis of anus without fistula 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.33 [0.05;32.76] C 0/1,233   1/4,932 1 1,233
ref
Total 1 studies 1.33 [0.05;32.76] 1 1,233
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pasternak, 2013Pasternak, 2013 1.33[0.05; 32.76]11,2330%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 Tags Adjustment   - No  - No 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 All studiesAll studies 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.05; 32.76]11,233 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 0.77[0.47; 1.28]6706486%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0