Ondansetron

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2852
R3867		 Huybrechts (Control exposed to other treatment), 2018 Atrioventricular septal defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 1.01 [0.53;1.92]
excluded (control group) 		12/55,579   49/185,699 61 55,579
ref
S2844
R3837		 Huybrechts (Unexposed control), 2018 Atrioventricular septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.99 [0.61;1.61] 17/88,446   422/1,727,546 439 88,446
ref
S2746
R3891		 Pasternak, 2013 Atrioventricular septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 4.00 [0.25;64.04] C 1/1,233   1/4,932 2 1,233
ref
Total 2 studies 1.03 [0.64;1.66] 441 89,679
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 0.99[0.61; 1.61]43988,44697%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 4.00[0.25; 64.04]21,2333%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.03[0.64; 1.66]44189,6790.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.64; 1.66]44189,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.64; 1.66]44189,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 Tags Adjustment   - No  - No 4.00[0.25; 64.04]21,233 -NAPasternak, 2013 1   - Yes  - Yes 0.99[0.61; 1.61]43988,446 -NAHuybrechts (Unexposed control), 2018 1 All studiesAll studies 1.03[0.64; 1.66]44189,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.72[0.77; 3.81]5,99991,74064%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 Pasternak, 2013 4 unexposed, sick controlsunexposed, sick controls 0.70[0.29; 1.67]192258 -NAParker, NBDPS study, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.01[0.53; 1.92]6155,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0