id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S4195 R9717 |
Lemon, 2019 | Neonatal ventricular septal defect | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 2.10 [1.10;4.00] | 24/3,727 22/5,779 | 46 | 3,727 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2852 R3865 |
Huybrechts (Control exposed to other treatment), 2018 | Ventricular septal defect | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
1.07 [0.93;1.23] excluded (control group) |
253/55,579 758/185,699 | 1,011 | 55,579 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2844 R3835 |
Huybrechts (Unexposed control), 2018 | Ventricular septal defect | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.06 [0.96;1.17] | 400/88,446 6,824/1,727,546 | 7,224 | 88,446 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2778 R3784 |
Fejzo (Mainly exposed to other treatements, sick), 2016 | Ventricular septal defect | 1st trimester | retrospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
2.32 [0.11;48.42] C excluded (control group) |
2/952 0/441 | 2 | 952 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2776 R3746 |
Fejzo (Unexposed control, disease free), 2016 | Ventricular septal defect | 1st trimester | retrospective cohort | unexposed, disease free | Adjustment: No | 0.67 [0.12;3.69] C | 2/952 4/1,286 | 6 | 952 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2746 R3889 |
Pasternak, 2013 | Ventricular septal defect | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: No | 1.41 [0.56;3.59] C | 6/1,233 17/4,932 | 23 | 1,233 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 1.26 [0.86;1.85] | 7,299 | 94,358 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Unexposed control; 2: Unexposed control, disease free;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded 2778, 2852