Ondansetron

Cleft lip with or without cleft palate

id	Study   Auto Zambelli-Weiner (Unexposed control, NOS), 2019Huybrechts (Control exposed to other treatment), 2018Huybrechts (Unexposed control), 2018Parker, BDS study, 2018Parker, NBDPS study, 2018Fejzo (Mainly exposed to other treatements, sick), 2016Fejzo (Unexposed control, disease free), 2016Pasternak, 2013Anderka, 2012	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S2852 R4648	Huybrechts (Control exposed to other treatment), 2018	Cleft lip and Cleft lip and palate	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	0.93 [0.68;1.27] C excluded (control group)	50/55,579   180/185,699	230	55,579		ref
S2844 R4649	Huybrechts (Unexposed control), 2018	Cleft lip and Cleft lip and palate	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	1.02 [0.82;1.28] C	81/88,446   1,545/1,727,925	1,626	88,446		ref
S2778 R3785	Fejzo (Mainly exposed to other treatements, sick), 2016	Cleft lip/palate	1st trimester	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.39 [0.06;34.20] C excluded (control group)	1/952   0/441	1	952		ref
S2776 R3747	Fejzo (Unexposed control, disease free), 2016	Cleft lip/palate	1st trimester	retrospective cohort	unexposed, disease free	Adjustment: No	0.68 [0.06;7.46] C	1/952   2/1,286	3	952		ref
S2746 R3895	Pasternak, 2013	Cleft lip with or without cleft palate	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: No	1.09 [0.30;3.92] C	3/1,233   11/4,932	14	1,233		ref
					Total	3 studies	1.02 [0.82;1.27]		1,643	90,631
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 2778, 2852