Ondansetron

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2852
R3875		 Huybrechts (Control exposed to other treatment), 2018 Cleft Palate 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 1.25 [0.89;1.75]
excluded (control group) 		46/55,579   120/185,699 166 55,579
ref
S2844
R3845		 Huybrechts (Unexposed control), 2018 Cleft Palate 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.20 [0.94;1.55] 65/88,446   987/1,727,546 1,052 88,446
ref
S2746
R3897		 Pasternak, 2013 Cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.80 [0.04;16.67] C 0/1,233   2/4,932 2 1,233
ref
Total 2 studies 1.20 [0.93;1.54] 1,054 89,679
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 1.20[0.94; 1.55]1,05288,44699%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.80[0.04; 16.67]21,2331%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.20[0.93; 1.54]1,05489,6790.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[0.93; 1.54]1,05489,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.93; 1.54]1,05489,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 Tags Adjustment   - No  - No 0.80[0.04; 16.67]21,233 -NAPasternak, 2013 1   - Yes  - Yes 1.20[0.93; 1.54]1,05288,446 -NAHuybrechts (Unexposed control), 2018 1 All studiesAll studies 1.20[0.93; 1.54]1,05489,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.98; 1.55]2,13390,5680%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sick controlsunexposed, sick controls 1.24[0.54; 2.83]1,23069385%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 Anderka, 2012 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.25[0.89; 1.75]16655,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0