Metoclopramide

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3267
R5279		 Huybrechts, 2018 Cleft lip and Cleft lip and palate 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 1.16 [0.81;1.66] C 54/52,809   68/77,165 122 52,809
ref
S2397
R2991		 Pasternak, 2013 Cleft lip with or without cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.81 [0.54;1.22] 31/28,486   147/113,698 178 28,486
ref
Total 2 studies 0.98 [0.69;1.40] 300 81,295
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts, 2018Huybrechts, 2018 1.16[0.81; 1.66]12252,80954%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.81[0.54; 1.22]17828,48646%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 41% 0.98[0.69; 1.40]30081,2950.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.98[0.69; 1.40]30081,29541%NAHuybrechts, 2018 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.81[0.54; 1.22]17828,486 -NAPasternak, 2013 1 exposed to other treatment, sickexposed to other treatment, sick 1.16[0.81; 1.66]12252,809 -NAHuybrechts, 2018 1 Tags Adjustment   - No  - No 1.16[0.81; 1.66]12252,809 -NAHuybrechts, 2018 1   - Yes  - Yes 0.81[0.54; 1.22]17828,486 -NAPasternak, 2013 1 All studiesAll studies 0.98[0.69; 1.40]30081,29541%NAHuybrechts, 2018 Pasternak, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.81[0.54; 1.22]17828,486 -NAPasternak, 2013 1 unexposed, sick controlsunexposed, sick controls 1.23[0.40; 3.75]93322 -NAAnderka, 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.16[0.81; 1.66]12252,809 -NAHuybrechts, 2018 10.510.01.0