Ondansetron

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2844
R3858		 Huybrechts (Unexposed control), 2018 Limb defects (other than musculoskeletal) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.03 [0.94;1.14] 437/88,446   7,229/1,727,546 7,666 88,446
ref
S2853
R3980		 Parker, BDS study, 2018 Limb deficiency 1st trimester case control unexposed, sick Adjustment: Yes 0.70 [0.30;1.60] 7/382   122/5,620 129 382
ref
S2756
R3697		 Parker, NBDPS study, 2018 Limb deficiency 1st trimester case control unexposed, sick Adjustment: Yes 0.80 [0.50;1.30] 16/269   585/7,083 601 269
ref
S2746
R3906		 Pasternak, 2013 Limb 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.04 [0.42;2.57] C 6/1,233   23/4,932 29 1,233
ref
Total 4 studies 1.02 [0.92;1.11] 8,425 90,330
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 1.03[0.94; 1.14]7,66688,44694%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, BDS study, 2018Parker, BDS study, 2018 0.70[0.30; 1.60]1293821%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.80[0.50; 1.30]6012694%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 1.04[0.42; 2.57]291,2331%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.02[0.92; 1.11]8,42590,3300.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.94; 1.13]7,69589,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.94; 1.13]7,69589,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 unexposed, sickunexposed, sick 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 Tags Adjustment   - No  - No 1.04[0.42; 2.57]291,233 -NAPasternak, 2013 1   - Yes  - Yes 1.02[0.92; 1.12]8,39689,0970%NAHuybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 3 All studiesAll studies 1.02[0.92; 1.11]8,42590,3300%NAHuybrechts (Unexposed control), 2018 Parker, BDS study, 2018 Parker, NBDPS study, 2018 Pasternak, 2013 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.11.10.5510.000Huybrechts (Unexposed control), 2018Parker, BDS study, 2018Parker, NBDPS study, 2018Pasternak, 2013

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.94; 1.13]7,69589,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 unexposed, sick controlsunexposed, sick controls 0.77[0.51; 1.17]7306510%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 20.510.01.0