Ondansetron

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3852
R8208		 Huybrechts, 2019 Oral clefts 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Intravenous 0.95 [0.63;1.43] -/23,866   -/1,762,018 - 23,866
ref
S2757
R3714		 Zambelli-Weiner (Unexposed control, NOS), 2019 Orofacial Defects 1st trimester nested case control unexposed (general population or NOS) excluded Adjustment: Yes 1.30 [0.75;2.25]
excluded (control group) 		13/891   1,433/114,539 1,446 891
ref
S3041
R4610		 Zambelli-Weiner (Unexposed control, sick), 2019 Orofacial Defects 1st trimester nested case control unexposed, sick Adjustment: Yes 1.43 [0.78;2.64] 13/4   1,433/1,433 1,446 4
ref
S2852
R3861		 Huybrechts (Control exposed to other treatment), 2018 Oral clefts 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 1.32 [1.03;1.70]
excluded (control group) 		84/55,579   219/185,699 303 55,579
ref
S2844
R3815		 Huybrechts (Unexposed control), 2018 Oral clefts 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.24 [1.03;1.48] 124/88,446   1,920/1,727,546 2,044 88,446
ref
S2746
R3894		 Pasternak, 2013 Orofacial clefts 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.92 [0.26;3.24] C 3/1,233   13/4,932 16 1,233
ref
Total 4 studies 1.20 [1.02;1.40] 3,506 113,549
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts, 2019Huybrechts, 2019 0.95[0.63; 1.43]-23,86615%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Zambelli-Weiner (Unexposed control, sick), 2019Zambelli-Weiner, 2019 1 1.43[0.78; 2.64]1,44647%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Huybrechts (Unexposed control), 2018Huybrechts, 2018 2 1.24[1.03; 1.48]2,04488,44677%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.92[0.26; 3.24]161,2332%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.20[1.02; 1.40]3,506113,5490.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, sick; 2: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.18[1.00; 1.39]2,060113,5450%NAHuybrechts, 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 case control studiescase control studies 1.43[0.78; 2.63]1,4464 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.18[1.00; 1.39]2,060113,5450%NAHuybrechts, 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sickunexposed, sick 1.43[0.78; 2.63]1,4464 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 Tags Adjustment   - No  - No 0.92[0.26; 3.24]161,233 -NAPasternak, 2013 1   - Yes  - Yes 1.20[1.02; 1.41]3,490112,3160%NAHuybrechts, 2019 Zambelli-Weiner (Unexposed control, sick), 2019 Huybrechts (Unexposed control), 2018 3 IntravenousIntravenous 0.95[0.63; 1.43]-23,866 -NAHuybrechts, 2019 1 All studiesAll studies 1.20[1.02; 1.40]3,506113,5490%NAHuybrechts, 2019 Zambelli-Weiner (Unexposed control, sick), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.51.70.7700.000Huybrechts, 2019Zambelli-Weiner (Unexposed control, sick), 2019Huybrechts (Unexposed control), 2018Pasternak, 2013

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 2852, 2757

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.19[1.02; 1.39]3,506114,4360%NAHuybrechts, 2019 Zambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 4 unexposed, sick controlsunexposed, sick controls 1.43[0.78; 2.63]1,4464 -NAZambelli-Weiner (Unexposed control, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.32[1.03; 1.70]30355,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0