Ondansetron

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3943		 Zambelli-Weiner (Unexposed control, NOS), 2019 Septal defects 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.44 [1.28;1.62] 301/1,179   28,666/141,772 28,967 1,179
ref
S2752
R3662		 Danielsson, 2014 Septum defect early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 2.05 [1.19;3.28] 17/1,349   10,491/1,501,434 10,508 1,349
ref
Total 2 studies 1.57 [1.17;2.12] 39,475 2,528
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 1.44[1.28; 1.62]28,9671,17975%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Danielsson, 2014Danielsson, 2014 2.05[1.19; 3.28]10,5081,34925%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 43% 1.57[1.17; 2.12]39,4752,5280.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.05[1.23; 3.40]10,5081,349 -moderateDanielsson, 2014 1 case control studiescase control studies 1.44[1.28; 1.62]28,9671,179 -moderateZambelli-Weiner (Unexposed control, NOS), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.57[1.17; 2.12]39,4752,52843%moderateZambelli-Weiner (Unexposed control, NOS), 2019 Danielsson, 2014 2 Tags Adjustment   - Yes  - Yes 1.57[1.17; 2.12]39,4752,52843%moderateZambelli-Weiner (Unexposed control, NOS), 2019 Danielsson, 2014 2 All studiesAll studies 1.57[1.17; 2.12]39,4752,52843%moderateZambelli-Weiner (Unexposed control, NOS), 2019 Danielsson, 2014 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.57[1.17; 2.12]39,4752,52843%NAZambelli-Weiner (Unexposed control, NOS), 2019 Danielsson, 2014 20.510.01.0