Ondansetron

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2757
R3947		 Zambelli-Weiner (Unexposed control, NOS), 2019 Atrioventricular septal defect 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 2.71 [1.62;4.52] 15/828   5,542/792,482 5,557 828
ref
S2852
R3867		 Huybrechts (Control exposed to other treatment), 2018 Atrioventricular septal defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 1.01 [0.53;1.92]
excluded (control group) 		12/55,579   49/185,699 61 55,579
ref
S2844
R3837		 Huybrechts (Unexposed control), 2018 Atrioventricular septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.99 [0.61;1.61] 17/88,446   422/1,727,546 439 88,446
ref
S2756
R3703		 Parker, NBDPS study, 2018 Atrioventricular septal defect 1st trimester case control unexposed, sick Adjustment: Yes 0.70 [0.30;1.70] 5/258   187/6,685 192 258
ref
S2746
R3891		 Pasternak, 2013 Atrioventricular septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 4.00 [0.25;64.04] C 1/1,233   1/4,932 2 1,233
ref
Total 4 studies 1.38 [0.65;2.93] 6,190 90,765
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zambelli-Weiner (Unexposed control, NOS), 2019Zambelli-Weiner, 2019 1 2.71[1.62; 4.52]5,55782834%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Huybrechts (Unexposed control), 2018Huybrechts, 2018 2 0.99[0.61; 1.61]43988,44634%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Parker, NBDPS study, 2018Parker, NBDPS study, 2018 0.70[0.30; 1.70]19225826%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 4.00[0.25; 64.04]21,2336%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 73% 1.38[0.65; 2.93]6,19090,7650.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, NOS; 2: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.64; 1.66]44189,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 1.44[0.38; 5.42]5,7491,08686%NAZambelli-Weiner (Unexposed control, NOS), 2019 Parker, NBDPS study, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.76[0.72; 4.29]5,99890,50776%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sickunexposed, sick 0.70[0.29; 1.67]192258 -NAParker, NBDPS study, 2018 1 Tags Adjustment   - No  - No 4.00[0.25; 64.04]21,233 -NAPasternak, 2013 1   - Yes  - Yes 1.29[0.58; 2.87]6,18889,53281%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Parker, NBDPS study, 2018 3 All studiesAll studies 1.38[0.65; 2.93]6,19090,76573%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Parker, NBDPS study, 2018 Pasternak, 2013 40.210.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.33.71.6970.000Zambelli-Weiner (Unexposed control, NOS), 2019Huybrechts (Unexposed control), 2018Parker, NBDPS study, 2018Pasternak, 2013

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.72[0.77; 3.81]5,99991,74064%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 Pasternak, 2013 4 unexposed, sick controlsunexposed, sick controls 0.70[0.29; 1.67]192258 -NAParker, NBDPS study, 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.01[0.53; 1.92]6155,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0