Antithyroid drugs

Table   Graphic  
  individual studies
OutcomeTE95% CIn casesn exposedkPub. bias All congenital malformations (majors, minors, majors and minors, or unspecified) Momotani, 1977 Momotani (MMI only), 1984 Wing, 1994 Di Gianantonio (MMI only), 2001 Azizi (MMI only), 2002 Rosenfeld (PTU only), 2009 Banhidy, 2011 Yoshihara, 2012 Gianetti, 2015 Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 Andersen, 2019 Yoshihara, 2021 131.23[1.09; 1.38]250,16520,031low Major congenital malformations Momotani (MMI only), 1984 Wing, 1994 Di Gianantonio (MMI only), 2001 Rosenfeld (PTU only), 2009 Yoshihara, 2012 Gianetti, 2015 61.32[0.95; 1.83]1973,475not evaluable Urinary malformations Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 Andersen, 2019 31.69[1.10; 2.61]17,72915,800not evaluable Genital anomalies Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 Andersen, 2019 31.17[0.96; 1.41]25,84815,800not evaluable Respiratory system anomalies Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 Andersen, 2019 31.16[0.67; 2.01]16,03715,800not evaluable Congenital heart defects Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 Andersen, 2019 31.33[0.98; 1.79]77,71315,800not evaluable Ear, face and neck anomalies Andersen 2017 (control unexposed, sick), 2017 Andersen, 2019 21.50[0.59; 3.82]9172,909not evaluable Eye defects Andersen 2017 (control unexposed, sick), 2017 Andersen, 2019 21.39[0.70; 2.74]2,4932,909not evaluable Limb defects Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 Andersen, 2019 31.08[0.82; 1.41]74,80015,800not evaluable Severe congenital heart defect Clementi, 2010 Yoshihara, 2012 20.63[0.04; 9.47]7392,757not evaluable Abdominal wall defects Andersen 2017 (control unexposed, sick), 2017 Andersen, 2019 23.37[1.63; 6.96]9332,909not evaluable Ano-rectal atresia and stenosis Yoshihara, 2012 Howley, 2017 Yoshihara, 2021 31.41[0.29; 6.91]1,0573,208not evaluable Cardiac septal defects Andersen 2014 (MMI only), 2014 11.87[1.14; 3.06]-1,097not evaluable Craniosynostosis Yoshihara, 2012 Besancon, 2014 Howley, 2017 31.53[0.43; 5.51]1,5372,684not evaluable Digestive system anomalies Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 21.36[1.08; 1.71]12,07013,337not evaluable Nervous system anomalies Andersen 2017 (control unexposed, sick), 2017 Seo, 2018 21.45[1.06; 2.00]5,88413,337not evaluable Omphalocele Clementi, 2010 Yoshihara, 2012 Yoshihara, 2021 33.02[0.56; 16.34]1653,321not evaluable Syndromes and chromosomal abnormalities Andersen 2017 (control unexposed, sick), 2017 Andersen, 2019 20.88[0.34; 2.27]5,5572,909not evaluable Aortic valve atresia/stenosis Yoshihara, 2012 Howley, 2017 21.75[0.07; 44.39]4942,643not evaluable Atresia of bile ducts Yoshihara, 2012 Yoshihara, 2021 20.48[0.06; 3.92]33,194not evaluable Carbimazole embryopathy Di Gianantonio (MMI only), 2001 Seo, 2018 25.24[0.80; 34.53]2,04813,095not evaluable Choanal atresia Barbero (MMI only), 2008 Clementi, 2010 212.25[5.02; 29.88]119139not evaluable Congenital hydronephrosis Yoshihara, 2012 Yoshihara, 2021 22.60[0.62; 10.95]103,194not evaluable Ear malformations Andersen 2017 (control unexposed, sick), 2017 117.48[0.84; 364.79]2446not evaluable Hypospadias Yoshihara, 2012 Yoshihara, 2021 21.85[0.27; 12.64]43,194not evaluable Oro-facial clefts Seo, 2018 Yoshihara, 2021 21.22[0.78; 1.90]3,46713,455not evaluable Other congenital malformations (Q80-84) Andersen 2017 (control unexposed, sick), 2017 10.18[0.01; 3.14]9446not evaluable Pulmonary valve stenosis Howley, 2017 Yoshihara, 2021 21.72[0.45; 6.64]1,519577not evaluable Situs inversus Clementi, 2010 Yoshihara, 2012 216.80[2.99; 94.32]272,757not evaluable Ventricular septal defect Yoshihara, 2012 Yoshihara, 2021 20.99[0.51; 1.91]373,194not evaluable Aplasia cutis congenita Yoshihara, 2012 110.90[0.62; 190.95]72,630not evaluable Atresia or stenosis of other parts of small intestine Yoshihara, 2012 12.17[0.09; 53.42]12,630not evaluable Atrial septal defect Yoshihara, 2012 11.45[0.13; 16.00]32,630not evaluable Brachydactyly Yoshihara, 2012 12.17[0.09; 53.42]12,630not evaluable Chromosomal abnormalities Gianetti, 2015 11.16[0.16; 8.29]4176not evaluable Cleft lip with or without cleft palate Yoshihara, 2012 10.36[0.03; 4.00]32,630not evaluable Club foot / Talipes equinovarus Yoshihara, 2012 10.24[0.01; 5.93]12,630not evaluable Coarctation of aorta Howley, 2017 13.99[1.02; 15.54]1,13714not evaluable Congenital cataract Yoshihara, 2012 10.24[0.01; 5.93]12,630not evaluable Diaphragmatic hernia Yoshihara, 2012 10.24[0.01; 5.93]12,630not evaluable Down syndrom / Trisomy 21 Yoshihara, 2012 11.81[0.35; 9.36]72,630not evaluable Eye, ear, face and neck malformations Seo, 2018 11.18[0.89; 1.56]9,49312,891not evaluable Gastroschisis Howley, 2017 12.43[0.52; 11.40]1,39413not evaluable Intestinal malrotation Yoshihara, 2012 10.24[0.03; 2.32]42,630not evaluable Multicystic renal dysplasia Yoshihara, 2012 10.72[0.05; 11.59]22,630not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Yoshihara, 2012 13.63[0.17; 75.58]22,630not evaluable Other congenital malformations (Q80 to Q99) Seo, 2018 11.25[0.96; 1.62]10,07912,891not evaluable Patent ductus arterious Yoshihara, 2012 17.99[0.44; 144.53]52,630not evaluable Polydactyly Yoshihara, 2021 12.53[0.10; 62.27]1564not evaluable Pulmonary artery stenosis Yoshihara, 2012 10.24[0.01; 5.93]12,630not evaluable0.0100.01.0