Bendroflumethiazide (versus unexposed) updated on 03-11-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14294
R56314		 Leather, 1968 Abortion during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indications Antihypertensive: Only chronic hypertension indication 0.13 [0.01;2.68] C 0/23   3/24 3 23
ref
Total 1 studies 0.13 [0.01;2.68] 3 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Leather, 1968Leather, 1968 0.13[0.01; 2.68]3230%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.13[0.01; 2.68]323 -NALeather, 1968 1 Type of controls unexposed, sickunexposed, sick 0.13[0.01; 2.68]323 -NALeather, 1968 1 Tags Adjustment   - Randomisation  - Randomisation 0.13[0.01; 2.68]323 -NALeather, 1968 1 Co-administrationCo-administration 0.13[0.01; 2.68]323 -NALeather, 1968 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 0.13[0.01; 2.68]323 -NALeather, 1968 1 All studiesAll studies 0.13[0.01; 2.68]323 -NALeather, 1968 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.13[0.01; 2.68]323 -NALeather, 1968 10.510.01.0