Beta-blockers (Ocular route only) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (Ocular route only) (versus unexposed) updated on 12-17-2024

Neonatal medical care

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17249 R72195	Kaufman - Beta-blockers, 2024	Neonatal intensive care unit stay	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	0.87 [0.15;4.98] ^C	5/48 2/17	7	48		ref
S14054 R55588	Pellegrino - Timolol, 2018	Neonatal Respiratory complication (apnea, cyanosis, grunting, inspiratory stridor, nasal flaring, poor feeding, and tachypnea (more than 60 breaths per minute))	throughout pregnancy	prospective cohort	unexposed, disease free	Adjustment: No	8.24 [0.50;136.65] ^C	1/22 1/174	2	22		ref
					Total	2 studies	2.02 [0.24;17.03]		9	70
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded