Hydrochlorothiazide (versus unexposed) updated on 03-11-2025

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14337
R56724		 Mabie, 1986 Perinatal death (stillbirth and neonatal deaths) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 2.82 [0.11;74.36] C 0/10   1/82 1 10
ref
Total 1 studies 2.82 [0.11;74.36] 1 10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Mabie, 1986Mabie, 1986 2.82[0.11; 74.36]1100%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.82[0.11; 74.36]110 -NAMabie, 1986 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.82[0.11; 74.36]110 -NAMabie, 1986 1 Tags Adjustment   - No  - No 2.82[0.11; 74.36]110 -NAMabie, 1986 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 2.82[0.11; 74.36]110 -NAMabie, 1986 1 All studiesAll studies 2.82[0.11; 74.36]110 -NAMabie, 1986 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.82[0.11; 74.36]110 -NAMabie, 1986 10.510.01.0