Hydrochlorothiazide (versus unexposed) updated on 03-11-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14414
R57237		 Medveczky, 2004 Neural-tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified Matched 4.30 [0.50;52.20] 1/2   1,201/39,351 1,202 2
ref
Total 1 studies 4.30 [0.42;43.94] 1,202 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Medveczky, 2004Medveczky, 2004 4.30[0.50; 52.20]1,20220%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 1 Tags Adjustment   - Yes  - Yes 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 1 MatchedMatched 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 1 All studiesAll studies 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.30[0.42; 43.94]1,2022 -NAMedveczky, 2004 10.510.01.0