Propranolol (versus unexposed) updated on 12-17-2024

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13914
R54439		 Duan, 2018 Low birth weight (birth weight <2500g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.50 [1.07;2.10] C 37/489   19,393/374,391 19,430 489
ref
S14240
R55941		 Ishibashi, 2017 Low birthweight infants (birth weight less than 2500 kg) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 1.92 [0.68;5.43] C 7/26   14/87 21 26
ref
Total 2 studies 1.53 [1.11;2.11] 19,451 515
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Duan, 2018Duan, 2018 1.50[1.07; 2.10]19,43048991%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Ishibashi, 2017Ishibashi, 2017 1.92[0.68; 5.43]21269%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: low Total (2 studies) I2 = 0% 1.53[1.11; 2.11]19,4515150.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.53[1.11; 2.11]19,4515150%NADuan, 2018 Ishibashi, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.50[1.07; 2.10]19,430489 -NADuan, 2018 1 unexposed, sickunexposed, sick 1.92[0.68; 5.43]2126 -NAIshibashi, 2017 1 Tags Adjustment   - No  - No 1.53[1.11; 2.11]19,4515150%NADuan, 2018 Ishibashi, 2017 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.50[1.07; 2.10]19,430489 -NADuan, 2018 1   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 1.92[0.68; 5.43]2126 -NAIshibashi, 2017 1 All studiesAll studies 1.53[1.11; 2.11]19,4515150%NADuan, 2018 Ishibashi, 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.50[1.07; 2.10]19,430489 -NADuan, 2018 1 unexposed, sick controlsunexposed, sick controls 1.92[0.68; 5.43]2126 -NAIshibashi, 2017 10.510.01.0