Hydroxychloroquine (Indication Antiphospholipid Syndrom)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13685
R53194		 Gerde, 2021 Early pregnancy losses <22 weeks throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 0.05 [0.01;0.24] C 2/69   12/32 14 69
ref
S13674
R53132		 Ye, 2017 Abortion within 10 weeks throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 0.36 [0.16;0.80] C 9/126   25/141 34 126
ref
S13718
R53441		 Sciascia, 2016 Spontaneous abortions before the 10th week throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Antiphospholipid syndrome (APS) 0.73 [0.36;1.46] C 16/51   46/119 62 51
ref
Total 3 studies 0.29 [0.09;0.95] 110 246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gerde, 2021Gerde, 2021 0.05[0.01; 0.24]146925%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Ye, 2017Ye, 2017 0.36[0.16; 0.80]3412637%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Sciascia, 2016Sciascia, 2016 0.73[0.36; 1.46]625138%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 79% 0.29[0.09; 0.95]1102460.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.29[0.09; 0.95]11024679%NAGerde, 2021 Ye, 2017 Sciascia, 2016 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.29[0.09; 0.95]11024679%NAGerde, 2021 Ye, 2017 Sciascia, 2016 3 Tags Adjustment   - No  - No 0.29[0.09; 0.95]11024679%NAGerde, 2021 Ye, 2017 Sciascia, 2016 3 Co-administrationCo-administration 0.15[0.02; 1.02]4819579%NAGerde, 2021 Ye, 2017 2 Indication HCQ   - Antiphospholipid syndrome (APS)  - Antiphospholipid syndrome (APS) 0.29[0.09; 0.95]11024679%NAGerde, 2021 Ye, 2017 Sciascia, 2016 3 All studiesAll studies 0.29[0.09; 0.95]11024679%NAGerde, 2021 Ye, 2017 Sciascia, 2016 30.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.29[0.09; 0.95]11024679%NAGerde, 2021 Ye, 2017 Sciascia, 2016 30.510.01.0