Hydroxychloroquine (Indication Antiphospholipid Syndrom)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13690
R53237		 Elsenity, 2022 Congenital anomalies throughout pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 0.21 [0.01;5.41] C 0/33   1/22 1 33
ref
S13674
R53136		 Ye, 2017 Fetal or neonatal malformations throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 0.98 [0.02;49.95] C 0/116   0/114 0 116
ref
Total 2 studies 0.39 [0.03;4.81] 1 149
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Elsenity, 2022Elsenity, 2022 0.21[0.01; 5.41]13359%ROB confusion: lowROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low Ye, 2017Ye, 2017 0.98[0.02; 49.95]011641%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.39[0.03; 4.81]11490.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.98[0.02; 49.95]-116 -NAYe, 2017 1 case control studiescase control studies 0 RCTRCT 0.21[0.01; 5.41]133 -NAElsenity, 2022 1 Type of controls unexposed, sickunexposed, sick 0.39[0.03; 4.81]11490%NAElsenity, 2022 Ye, 2017 2 Tags Adjustment   - No  - No 0.98[0.02; 49.95]-116 -NAYe, 2017 1   - Randomisation  - Randomisation 0.21[0.01; 5.41]133 -NAElsenity, 2022 1 Co-administrationCo-administration 0.39[0.03; 4.81]11490%NAElsenity, 2022 Ye, 2017 2 Indication HCQ   - Antiphospholipid syndrome (APS)  - Antiphospholipid syndrome (APS) 0.39[0.03; 4.81]11490%NAElsenity, 2022 Ye, 2017 2 All studiesAll studies 0.39[0.03; 4.81]11490%NAElsenity, 2022 Ye, 2017 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.39[0.03; 4.81]11490%NAElsenity, 2022 Ye, 2017 20.510.01.0