Hydroxychloroquine (Indication Antiphospholipid Syndrom)

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13690
R53232		 Elsenity, 2022 Apgar score at 5 minutes < 7 throughout pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indication HCQ: Antiphospholipid syndrome (APS) 0.38 [0.19;0.75] 8/33   14/22 22 33
ref
Total 1 studies 0.38 [0.19;0.75] 22 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Elsenity, 2022Elsenity, 2022 0.38[0.19; 0.75]22330%ROB confusion: lowROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.38[0.19; 0.75]2233 -NAElsenity, 2022 1 Type of controls unexposed, sickunexposed, sick 0.38[0.19; 0.75]2233 -NAElsenity, 2022 1 Tags Adjustment   - Randomisation  - Randomisation 0.38[0.19; 0.75]2233 -NAElsenity, 2022 1 Co-administrationCo-administration 0.38[0.19; 0.75]2233 -NAElsenity, 2022 1 Indication HCQ   - Antiphospholipid syndrome (APS)  - Antiphospholipid syndrome (APS) 0.38[0.19; 0.75]2233 -NAElsenity, 2022 1 All studiesAll studies 0.38[0.19; 0.75]2233 -NAElsenity, 2022 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.38[0.19; 0.75]2233 -NAElsenity, 2022 10.510.01.0