Hydroxychloroquine (Indication Antiphospholipid Syndrom)

Maternal consequences (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13717
R53437		 Ruffatti, 2018 Severe pregnancy complications during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Indication HCQ: Antiphospholipid syndrome (APS) 0.32 [0.14;0.72] C 19/94   16/36 35 94
ref
Total 1 studies 0.32 [0.14;0.72] 35 94
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ruffatti, 2018Ruffatti, 2018 0.32[0.14; 0.72]35940%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.32[0.14; 0.72]3594 -NARuffatti, 2018 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.32[0.14; 0.72]3594 -NARuffatti, 2018 1 Tags Adjustment   - No  - No 0.32[0.14; 0.72]3594 -NARuffatti, 2018 1 Indication HCQ   - Antiphospholipid syndrome (APS)  - Antiphospholipid syndrome (APS) 0.32[0.14; 0.72]3594 -NARuffatti, 2018 1 All studiesAll studies 0.32[0.14; 0.72]3594 -NARuffatti, 2018 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.32[0.14; 0.72]3594 -NARuffatti, 2018 10.510.01.0