Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Extremely preterm (< 28 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13650
R52953		 Clowse, 2006 Extreme preterm (20–27.9 weeks) throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 1.32 [0.48;3.61] C 6/49   15/157 21 49
ref
Total 1 studies 1.32 [0.48;3.61] 21 49
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clowse, 2006Clowse, 2006 1.32[0.48; 3.61]21490%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.32[0.48; 3.61]2149 -NAClowse, 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.32[0.48; 3.61]2149 -NAClowse, 2006 1 Tags Adjustment   - No  - No 1.32[0.48; 3.61]2149 -NAClowse, 2006 1 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.32[0.48; 3.61]2149 -NAClowse, 2006 1 All studiesAll studies 1.32[0.48; 3.61]2149 -NAClowse, 2006 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.32[0.48; 3.61]2149 -NAClowse, 2006 10.510.01.0