Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Abruptio placentae (retroplacental hematoma)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13715
R53424		 Seo, 2019 Placenta abruption throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indication HCQ: Systemic lupus erythematosus (SLE) 3.68 [0.40;33.76] C 4/80   1/71 5 80
ref
Total 1 studies 3.68 [0.40;33.76] 5 80
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo, 2019Seo, 2019 3.68[0.40; 33.76]5800%ROB confusion: seriousROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.68[0.40; 33.76]580 -NASeo, 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.68[0.40; 33.76]580 -NASeo, 2019 1 Tags Adjustment   - No  - No 3.68[0.40; 33.76]580 -NASeo, 2019 1 Indication HCQ   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 3.68[0.40; 33.76]580 -NASeo, 2019 1 All studiesAll studies 3.68[0.40; 33.76]580 -NASeo, 2019 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.68[0.40; 33.76]580 -NASeo, 2019 10.510.01.0