Bupropion (Smoking cessation indication) updated on 07-01-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13463
R51844		 Tran (Controls exposed to Nicotine replacement therapy), 2020 Preterm (< 37 weeks, medically indicated or spontaneous) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Indications Bupropion: Smoking cessation Monotherapy: no or not specified 0.44 [0.22;0.87] C
excluded (control group) 		12/232   36/328 48 232
ref
S13464
R51851		 Tran (Controls unexposed, sick), 2020 Preterm (< 37 weeks, medically indicated or spontaneous) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Bupropion: Smoking cessation Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.62 [0.34;1.11] 12/232   192/2,320 204 232
ref
S13459
R51836		 Bérard (Controls exposed to nicotine patch), 2016 Prematurity (birth before the 37th weeks of gestation) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes Indications Bupropion: Smoking cessation Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.68 [0.13;3.53]
excluded (control group) 		2/72   25/316 27 72
ref
S13460
R51838		 Bérard (Controls unexposed, sick), 2016 Prematurity (birth before the 37th weeks of gestation) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Bupropion: Smoking cessation Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.12 [0.03;0.50] 2/72   240/900 242 72
ref
Total 2 studies 0.31 [0.06;1.52] 446 304
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tran (Controls unexposed, sick), 2020Tran, 2020 1 0.62[0.34; 1.11]20423258%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Bérard (Controls unexposed, sick), 2016Bérard, 2016 2 0.12[0.03; 0.50]2427242%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 78% 0.31[0.06; 1.52]4463040.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 2 Tags Adjustment   - Yes  - Yes 0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 2 Indications Bupropion   - Smoking cessation  - Smoking cessation 0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 2 Monotherapy   - no or not specified  - no or not specified 0.62[0.34; 1.12]204232 -NATran (Controls unexposed, sick), 2020 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.12[0.03; 0.49]24272 -NABérard (Controls unexposed, sick), 2016 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 2 All studiesAll studies 0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13459, 13463

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.31[0.06; 1.52]44630478%NATran (Controls unexposed, sick), 2020 Bérard (Controls unexposed, sick), 2016 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.47[0.25; 0.88]753040%NATran (Controls exposed to Nicotine replacement therapy), 2020 Bérard (Controls exposed to nicotine patch), 2016 20.510.01.0