Bupropion (Smoking cessation indication) updated on 07-01-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13461
R51840		 Kranzler, 2021 5-minute Apgar score <7 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Bupropion: Smoking cessation Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.18 [0.01;3.91] C 0/61   2/58 2 61
ref
Total 1 studies 0.18 [0.01;3.91] 2 61
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kranzler, 2021Kranzler, 2021 0.18[0.01; 3.91]2610%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: lowROB reporting: low0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.18[0.01; 3.91]261 -NAKranzler, 2021 1 Type of controls unexposed, sickunexposed, sick 0.18[0.01; 3.91]261 -NAKranzler, 2021 1 Tags Adjustment   - Randomisation  - Randomisation 0.18[0.01; 3.91]261 -NAKranzler, 2021 1 Indications Bupropion   - Smoking cessation  - Smoking cessation 0.18[0.01; 3.91]261 -NAKranzler, 2021 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.18[0.01; 3.91]261 -NAKranzler, 2021 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.18[0.01; 3.91]261 -NAKranzler, 2021 1 All studiesAll studies 0.18[0.01; 3.91]261 -NAKranzler, 2021 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.18[0.01; 3.91]261 -NAKranzler, 2021 10.510.01.0