Bupropion (Smoking cessation indication) updated on 07-01-2025

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18329
R77244		 Tran, 2025 Ear anomalies 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 9.90 [0.20;499.28] C 0/749   0/7,410 0 749
ref
Total 1 studies 9.90 [0.20;499.28] 0 749
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tran, 2025Tran, 2025 9.90[0.20; 499.28]07490%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 9.90[0.20; 499.28]-749 -NATran, 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 9.90[0.20; 499.28]-749 -NATran, 2025 1 Tags Adjustment   - No  - No 9.90[0.20; 499.28]-749 -NATran, 2025 1 All studiesAll studies 9.90[0.20; 499.28]-749 -NATran, 2025 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 9.90[0.20; 499.28]-749 -NATran, 2025 10.510.01.0