Bupropion (Smoking cessation indication) updated on 07-01-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18329
R77245		 Tran, 2025 Ventricular septal defect 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.79 [0.62;5.16] 4/749   22/7,410 26 749
ref
Total 1 studies 1.79 [0.62;5.16] 26 749
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tran, 2025Tran, 2025 1.79[0.62; 5.16]267490%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.79[0.62; 5.16]26749 -NATran, 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.79[0.62; 5.16]26749 -NATran, 2025 1 Tags Adjustment   - Yes  - Yes 1.79[0.62; 5.16]26749 -NATran, 2025 1 All studiesAll studies 1.79[0.62; 5.16]26749 -NATran, 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.79[0.62; 5.16]26749 -NATran, 2025 10.510.01.0