Methyldopa (versus unexposed) updated on 03-11-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14346
R56774		 Kayser, 2020 Neonatal disorders (bradycardia, hypoglycemia or respiratory disorders) days before delivery prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.53 [0.86;2.72] C 19/199   38/588 57 199
ref
S14354
R56816		 Chan, 2010 Neonatal Complications during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 2.00 [0.64;6.25] C 8/25   8/42 16 25
ref
Total 2 studies 1.61 [0.97;2.70] 73 224
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kayser, 2020Kayser, 2020 1.53[0.86; 2.72]5719980%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Chan, 2010Chan, 2010 2.00[0.64; 6.25]162520%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: lowROB reporting: moderate Total (2 studies) I2 = 0% 1.61[0.97; 2.70]732240.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.61[0.97; 2.70]732240%NAKayser, 2020 Chan, 2010 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.97; 2.70]732240%NAKayser, 2020 Chan, 2010 2 Tags Adjustment   - No  - No 1.61[0.97; 2.70]732240%NAKayser, 2020 Chan, 2010 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.61[0.97; 2.70]732240%NAKayser, 2020 Chan, 2010 2 MatchedMatched 2.00[0.64; 6.25]1625 -NAChan, 2010 1 All studiesAll studies 1.61[0.97; 2.70]732240%NAKayser, 2020 Chan, 2010 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.97; 2.70]732240%NAKayser, 2020 Chan, 2010 20.510.01.0