Methyldopa (versus unexposed) updated on 03-11-2025

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17243
R72158		 Al Khalaf (Controls unexposed, disease free), 2022 Very preterm birth (less than 32 weeks) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 5.93 [4.84;7.26] C
excluded (control group) 		100/1,760   17,507/1,739,944 17,607 1,760
ref
S17244
R72165		 Al Khalaf (Controls unexposed, sick), 2022 Very preterm birth (less than 32 weeks) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 2.26 [1.77;2.88] C 100/1,760   203/7,809 303 1,760
ref
Total 1 studies 2.26 [1.77;2.88] 303 1,760
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Al Khalaf (Controls unexposed, sick), 2022Al Khalaf, 2022 1 2.26[1.77; 2.88]3031,7600%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.26[1.77; 2.88]3031,760 -NAAl Khalaf (Controls unexposed, sick), 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.26[1.77; 2.88]3031,760 -NAAl Khalaf (Controls unexposed, sick), 2022 1 Tags Adjustment   - No  - No 2.26[1.77; 2.88]3031,760 -NAAl Khalaf (Controls unexposed, sick), 2022 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 2.26[1.77; 2.88]3031,760 -NAAl Khalaf (Controls unexposed, sick), 2022 1 All studiesAll studies 2.26[1.77; 2.88]3031,760 -NAAl Khalaf (Controls unexposed, sick), 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17243

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.93[4.84; 7.26]17,6071,760 -NAAl Khalaf (Controls unexposed, disease free), 2022 1 unexposed, sick controlsunexposed, sick controls 2.26[1.77; 2.88]3031,760 -NAAl Khalaf (Controls unexposed, sick), 2022 10.510.01.0