Methyldopa (versus unexposed) updated on 03-11-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14364
R56879		 Orbach, 2013 Apgar score <=7 at 5 min 3rd trimester retrospective cohort (claims database) unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.84 [1.50;5.38] 10/340   1,026/97,820 1,036 340
ref
S14394
R57128		 Sibai, 1990 Apgar score <7 at 5 minutes 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.50 [0.09;2.80] C 2/88   4/90 6 88
ref
S14281
R56179		 Fidler, 1983 Apgar score < 7 (at 5 min) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 0.63 [0.06;6.24] C 1/49   3/94 4 49
ref
Total 3 studies 1.27 [0.35;4.60] 1,046 477
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Orbach, 2013Orbach, 2013 2.84[1.50; 5.38]1,03634051%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Sibai, 1990Sibai, 1990 0.50[0.09; 2.80]68828%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Fidler, 1983Fidler, 1983 0.63[0.06; 6.24]44920%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 56% 1.27[0.35; 4.60]1,0464770.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.04[0.60; 6.92]1,04038935%NAOrbach, 2013 Fidler, 1983 2 case control studiescase control studies 0 RCTRCT 0.50[0.09; 2.80]688 -NASibai, 1990 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.04[0.60; 6.92]1,04038935%NAOrbach, 2013 Fidler, 1983 2 unexposed, sickunexposed, sick 0.50[0.09; 2.80]688 -NASibai, 1990 1 Tags Adjustment   - No  - No 0.63[0.06; 6.24]449 -NAFidler, 1983 1   - Randomisation  - Randomisation 0.50[0.09; 2.80]688 -NASibai, 1990 1   - Yes  - Yes 2.84[1.50; 5.38]1,036340 -NAOrbach, 2013 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.04[0.60; 6.92]1,04038935%NAOrbach, 2013 Fidler, 1983 2   - Only chronic hypertension indication  - Only chronic hypertension indication 0.50[0.09; 2.80]688 -NASibai, 1990 1 MatchedMatched 0.63[0.06; 6.24]449 -NAFidler, 1983 1 All studiesAll studies 1.27[0.35; 4.60]1,04647756%NAOrbach, 2013 Sibai, 1990 Fidler, 1983 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.04[0.60; 6.92]1,04038935%NAOrbach, 2013 Fidler, 1983 2 unexposed, sick controlsunexposed, sick controls Out of scale0.50[0.09; 2.80]688 -NASibai, 1990 10.510.01.0