Methyldopa (versus unexposed) updated on 03-11-2025

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14364
R56878		 Orbach, 2013 Apgar score <=7 at 1 min 3rd trimester retrospective cohort (claims database) unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.95 [1.40;2.70] 43/340   5,790/97,820 5,833 340
ref
Total 1 studies 1.95 [1.40;2.71] 5,833 340
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Orbach, 2013Orbach, 2013 1.95[1.40; 2.70]5,8333400%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.95[1.40; 2.71]5,833340 -NAOrbach, 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.95[1.40; 2.71]5,833340 -NAOrbach, 2013 1 Tags Adjustment   - Yes  - Yes 1.95[1.40; 2.71]5,833340 -NAOrbach, 2013 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.95[1.40; 2.71]5,833340 -NAOrbach, 2013 1 All studiesAll studies 1.95[1.40; 2.71]5,833340 -NAOrbach, 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.95[1.40; 2.71]5,833340 -NAOrbach, 2013 10.510.01.0