Duloxetine updated on 07-01-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11681
R42905		 Ankarfeldt b (Controls unexposed, sick), 2021 Elective abortions (observation time was throughout the pregnancy) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.41 [1.21;1.64] 401/1,197   318/1,376 719 1,197
ref
S11680
R42903		 Ankarfeldt b Controls unexposed, NOS), 2021 Elective abortions (observation time was throughout the pregnancy) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.45 [1.31;1.60]
excluded (control group) 		401/1,197   148,449/987,200 148,850 1,197
ref
S11788
R43370		 Ozturk, 2016 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.59 [0.16;78.35] C 0/3   14/275 14 3
ref
Total 2 studies 1.41 [1.21;1.64] 733 1,200
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ankarfeldt b (Controls unexposed, sick), 2021Ankarfeldt b, 2021 1 1.41[1.21; 1.64]7191,197100%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: low Ozturk, 2016Ozturk, 2016 3.59[0.16; 78.35]1430%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.41[1.21; 1.64]7331,2000.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.41[1.21; 1.64]7331,2000%NAAnkarfeldt b (Controls unexposed, sick), 2021 Ozturk, 2016 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.59[0.16; 78.35]143 -NAOzturk, 2016 1 unexposed, sickunexposed, sick 1.41[1.21; 1.64]7191,197 -NAAnkarfeldt b (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 3.59[0.16; 78.35]143 -NAOzturk, 2016 1   - Yes  - Yes 1.41[1.21; 1.64]7191,197 -NAAnkarfeldt b (Controls unexposed, sick), 2021 1 Monotherapy   - no or not specified  - no or not specified 1.41[1.21; 1.64]7331,2000%NAAnkarfeldt b (Controls unexposed, sick), 2021 Ozturk, 2016 2 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.41[1.21; 1.64]7191,197 -NAAnkarfeldt b (Controls unexposed, sick), 2021 1 All studiesAll studies 1.41[1.21; 1.64]7331,2000%NAAnkarfeldt b (Controls unexposed, sick), 2021 Ozturk, 2016 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11680

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.45[1.31; 1.60]148,8641,2000%NAAnkarfeldt b Controls unexposed, NOS), 2021 Ozturk, 2016 2 unexposed, sick controlsunexposed, sick controls 1.41[1.21; 1.64]7191,197 -NAAnkarfeldt b (Controls unexposed, sick), 2021 10.510.01.0