Duloxetine updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11682
R42908		 Ankarfeldt a (Controls unexposed, NOS), 2021 Stillbirth (> 22 weeks of pregnancy) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.18 [0.43;3.19]
excluded (control group) 		5/1,581   17/6,324 22 1,581
ref
S11683
R42924		 Ankarfeldt a (Controls unexposed, sick), 2021 Stillbirth (> 22 weeks of pregnancy) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.83 [0.25;2.73] 5/1,559   6/1,561 11 1,559
ref
Total 1 studies 0.83 [0.25;2.74] 11 1,559
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ankarfeldt a (Controls unexposed, sick), 2021Ankarfeldt a, 2021 1 0.83[0.25; 2.73]111,5590%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 Tags Adjustment   - Yes  - Yes 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 Monotherapy   - no or not specified  - no or not specified 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 1 All studiesAll studies 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11682

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.18[0.43; 3.21]221,581 -NAAnkarfeldt a (Controls unexposed, NOS), 2021 1 unexposed, sick controlsunexposed, sick controls 0.83[0.25; 2.74]111,559 -NAAnkarfeldt a (Controls unexposed, sick), 2021 10.510.01.0