Duloxetine updated on 07-01-2025

Abdominal wall defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11682
R42914		 Ankarfeldt a (Controls unexposed, NOS), 2021 Abdominal wall malformations 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 2.00 [0.37;10.92]
excluded (control group) 		-/1,438   -/5,751 - 1,438
ref
S11747
R43172		 Huybrechts (Controls unexposed, NOS), 2020 Musculoskeletal (no limbs, includes omphalocele ad gastroschisis) malformations 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 0.70 [0.38;1.30]
excluded (control group) 		-/2,532   -/- - 2,532
ref
S11748
R43186		 Huybrechts (Controls unexposed, sick), 2020 Musculoskeletal (no limbs, includes omphalocele ad gastroschisis) malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.45 [0.21;0.95] -/2,532   -/2,456 - 2,532
ref
Total 1 studies 0.45 [0.21;0.96] 0 2,532
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2020Huybrechts, 2020 1 0.45[0.21; 0.95]-2,5320%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 1 Tags Adjustment   - Yes  - Yes 0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 1 Monotherapy   - no or not specified  - no or not specified 0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 1 All studiesAll studies 0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11747, 11682

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.87[0.38; 2.00]-3,97023%NAAnkarfeldt a (Controls unexposed, NOS), 2021 Huybrechts (Controls unexposed, NOS), 2020 2 unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.21; 0.96]-2,532 -NAHuybrechts (Controls unexposed, sick), 2020 10.510.01.0