Duloxetine updated on 07-01-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18308
R77103		 Martin, 2024 Low Apgar score at 5 min (<7) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.68 [1.23;2.30] 44/1,517   30,996/2,078,011 31,040 1,517
ref
S13147
R50192		 Marks (Controls exposed to Bupropion), 2021 5 Min APGAR <7 during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.34 [0.78;2.30] C 22/139   50/406 72 139
ref
Total 2 studies 1.59 [1.21;2.08] 31,112 1,656
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Martin, 2024Martin, 2024 1.68[1.23; 2.30]31,0401,51775%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Marks (Controls exposed to Bupropion), 2021Marks, 2021 1 1.34[0.78; 2.30]7213925%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.59[1.21; 2.08]31,1121,6560.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Bupropion;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.59[1.21; 2.08]31,1121,6560%NAMartin, 2024 Marks (Controls exposed to Bupropion), 2021 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.68[1.23; 2.30]31,0401,517 -NAMartin, 2024 1 exposed to other treatment, sickexposed to other treatment, sick 1.34[0.78; 2.30]72139 -NAMarks (Controls exposed to Bupropion), 2021 1 Tags Adjustment   - No  - No 1.34[0.78; 2.30]72139 -NAMarks (Controls exposed to Bupropion), 2021 1   - Yes  - Yes 1.68[1.23; 2.30]31,0401,517 -NAMartin, 2024 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.59[1.21; 2.08]31,1121,6560%NAMartin, 2024 Marks (Controls exposed to Bupropion), 2021 2 All studiesAll studies 1.59[1.21; 2.08]31,1121,6560%NAMartin, 2024 Marks (Controls exposed to Bupropion), 2021 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.68[1.23; 2.30]31,0401,517 -NAMartin, 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.34[0.78; 2.30]72139 -NAMarks (Controls exposed to Bupropion), 2021 10.510.01.0