Trazodone updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11790
R43381		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 15.84 [0.30;825.45] C 0/1   15/261 15 1
ref
S11763
R43212		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 25.11 [0.47;1334.55] C 0/1   9/248 9 1
ref
Total 2 studies 19.92 [1.21;328.36] 24 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 15.84[0.30; 825.45]15150%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yaris, 2005Yaris, 2005 25.11[0.47; 1334.55]9150%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 19.92[1.21; 328.36]2420.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 19.92[1.21; 328.36]2420%NAOzturk, 2016 Yaris, 2005 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 19.92[1.21; 328.36]2420%NAOzturk, 2016 Yaris, 2005 2 Tags Adjustment   - No  - No 19.92[1.21; 328.36]2420%NAOzturk, 2016 Yaris, 2005 2 Monotherapy   - no or not specified  - no or not specified 19.92[1.21; 328.36]2420%NAOzturk, 2016 Yaris, 2005 2 All studiesAll studies 19.92[1.21; 328.36]2420%NAOzturk, 2016 Yaris, 2005 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale19.92[1.21; 328.36]2420%NAOzturk, 2016 Yaris, 2005 20.510.01.0