Trazodone - Medication and Pregnancy KB

Trazodone updated on 07-01-2025

Congenital heart defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18172 R76411	Chan (Controls exposed to SSRIs), 2024	Cardiac malformations	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	0.55 [0.03;9.25] ^C excluded (control group)	0/35 24/956	24	35		ref
S18153 R76310	Chan (Controls unexposed, pop general), 2024	Cardiac malformations	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	0.81 [0.05;13.25] ^C	0/35 8,107/462,377	8,107	35		ref
					Total	1 studies	0.81 [0.05;13.25]		8,107	35
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, pop general;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18172