Trazodone updated on 07-01-2025

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11825
R43435		 Khazaie (Controls exposed to diphenhydramine), 2013 Neonatal intensive care 3rd trimester randomized controlled trial exposed to other treatment, sick excluded Adjustment: Randomisation Indication: Insomnia Monotherapy 1.06 [0.02;56.24] C
excluded (control group) 		0/18   0/19 0 18
ref
S11826
R43436		 Khazaie (Controls unexposed, sick), 2013 Neonatal intensive care 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indication: Insomnia Monotherapy Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.00 [0.02;53.28] C 0/18   0/18 0 18
ref
Total 1 studies 1.00 [0.02;53.28] 0 18
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Khazaie (Controls unexposed, sick), 2013Khazaie, 2013 1 1.00[0.02; 53.28]0180%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 Type of controls unexposed, sickunexposed, sick 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 Tags Adjustment   - Randomisation  - Randomisation 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 Indication   - Insomnia  - Insomnia 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 MonotherapyMonotherapy 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 All studiesAll studies 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11825

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.00[0.02; 53.28]-18 -NAKhazaie (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.02; 56.24]-18 -NAKhazaie (Controls exposed to diphenhydramine), 2013 10.510.01.0